Modified on: February 27th, 2023
This report provides exploratory and preliminary correlation analyses between sex hormones and T2 final hippocampal subfield volume data from the Healthy Aging Study sample that have completed the spatial navigation study.
Cleaning data steps included (T2 subfields):
Filter participants that have useable T2 subfield data from scan and completed spatial navigation behavior
Select sex hormone measures from when spatial study was conducted
Values were already averaged together (left and right) and already corrected with TIV
For left and right subfields, they have already been corrected with TIV
Calculating Total Hippocampal Volume:
Sum up the averaged CA1, CA23, DG, SUB to get T2 total hippocampal volumes
Left and right volumes are by adding respective left and right subfields
Calculating Total MTL:
Sum up the averaged CA1, CA23, DG, SUB, ERC, PHC, PRC to get MTL volume
Left and right volumes are by adding respective left and right subfields
| Sex | n | Mean Age | SD Age |
|---|---|---|---|
| Female | 46 | 49.98 | 3.19 |
| Male | 14 | 49.71 | 3.52 |
Above table shows the table of sample size and mean and standard deviation of age by sex for overall group who have completed spatial behavior and have a useable T2hipp scan.
Shapiro-Wilk’s test reveal that MAZE accuracy for all and MAZE moves and path efficiency for overall, women groups were also not normally distributed. Behavior and volume correlations will be Spearman rank
All correlations are Spearman.
All correlations are Spearman.
All correlations are Spearman.
All Spearman correlations except for men (Pearson).
All Spearman correlations except for men (Pearson).
All Spearman correlations except for men (Pearson).
All correlations are Spearman except for men (Pearson)
All correlations are Spearman except for men (Pearson)
All correlations are Spearman except for men (Pearson)
All correlations are Spearman
All correlations are Spearman
All correlations are Spearman
All correlations are Spearman except for men (Pearson)
All correlations are Spearman except for men (Pearson)
All correlations are Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
All correlations were Spearman
All correlations were Spearman
All correlations were Spearman
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
All correlations are Spearman
All correlations are Spearman
All correlations are Spearman
All correlations are Spearman except for men (Pearson)
All correlations are Spearman except for men (Pearson)
All correlations are Spearman except for men (Pearson)
All correlations are Spearman except for men (Pearson)
All correlations are Spearman except for men (Pearson)
All correlations are Spearman except for men (Pearson)
All correlations were Spearman
All correlations were Spearman
All correlations were Spearman
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
All correlations are Spearman except for men
All correlations are Spearman except for men
All correlations are Spearman except for men
All correlations were Spearman
All correlations were Spearman
All correlations were Spearman
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
All correlations are Spearman except for men
All correlations are Spearman except for men
All correlations are Spearman except for men
All correlations were Spearman
All correlations were Spearman
All correlations were Spearman
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
All correlations are Spearman except for men
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
All correlations were Spearman
All correlations were Spearman
All correlations were Spearman
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
Alll correlations were Spearman except for men
All correlations were Spearman except for men
All correlations were Spearman except for men
All correlations were Spearman
All correlations were Spearman
All correlations were Spearman
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
All correlations were Spearman except for men (Pearson)
Alll correlations were Spearman except for men
All correlations were Spearman except for men
All correlations were Spearman except for men
Sample included HAS participants who had a T2 hipp scan and completed spatial navigation behavior for MAZE.
Total hipp volume was negatively correlated with path efficiency for men.
There were no significant or marginal correlations observed for MTL and MAZE behaviors.
There were no significant or marginal correlations observed for MAZE accuracy.
MAZE higher moves made was significantly negatively associated with higher right PHC volume in overall (p < 0.05, Spearman).
MAZE path efficiency was significantly positively associated with higher left DG in men. Path efficiency was negatively associated with total left hipp volume and right PHC volume in men. Negative correlations are also observed with averaged PRC volume for overall, and left PRC volumes for overall and for men.