Modified on: February 27th, 2023

Overview

This report provides exploratory and preliminary correlation analyses between sex hormones and T2 final hippocampal subfield volume data from the Healthy Aging Study sample that have completed the spatial navigation study.

Cleaning data steps included (T2 subfields):

  1. Filter participants that have useable T2 subfield data from scan and completed spatial navigation behavior

  2. Select sex hormone measures from when spatial study was conducted

  3. Values were already averaged together (left and right) and already corrected with TIV

For left and right subfields, they have already been corrected with TIV

Calculating Total Hippocampal Volume:

  • Sum up the averaged CA1, CA23, DG, SUB to get T2 total hippocampal volumes

  • Left and right volumes are by adding respective left and right subfields

Calculating Total MTL:

  • Sum up the averaged CA1, CA23, DG, SUB, ERC, PHC, PRC to get MTL volume

  • Left and right volumes are by adding respective left and right subfields

Sample size and age for women and men grouped by overall completion of MAZE behavior with useable T2hipp data.
Sex n Mean Age SD Age
Female 46 49.98 3.19
Male 14 49.71 3.52

Above table shows the table of sample size and mean and standard deviation of age by sex for overall group who have completed spatial behavior and have a useable T2hipp scan.

Behavioral Distributions

Shapiro-Wilk’s test reveal that MAZE accuracy for all and MAZE moves and path efficiency for overall, women groups were also not normally distributed. Behavior and volume correlations will be Spearman rank

Total Hippocampal Volume

Behavioral Correlations

MAZE

Accuracy

All correlations are Spearman.

LEFT

All correlations are Spearman.

Moves

All Spearman correlations except for men (Pearson).

LEFT

All Spearman correlations except for men (Pearson).

RIGHT

All Spearman correlations except for men (Pearson).

Path Efficiency

All correlations are Spearman except for men (Pearson)

LEFT

All correlations are Spearman except for men (Pearson)

RIGHT

All correlations are Spearman except for men (Pearson)

MTL

Behavioral Correlations

MAZE

Accuracy

All correlations are Spearman

LEFT

All correlations are Spearman

RIGHT

All correlations are Spearman

Moves

All correlations are Spearman except for men (Pearson)

LEFT

All correlations are Spearman except for men (Pearson)

RIGHT

All correlations are Spearman except for men (Pearson)

Path Efficiency

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

T2 Subfield Volume

CA1

Behavioral Correlations

MAZE

Accuracy

All correlations were Spearman

LEFT

All correlations were Spearman

RIGHT

All correlations were Spearman

Moves

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

Path Efficiency

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

CA2/3

Behavioral Correlations

MAZE

Accuracy

All correlations are Spearman

LEFT

All correlations are Spearman

RIGHT

All correlations are Spearman

Moves

All correlations are Spearman except for men (Pearson)

LEFT

All correlations are Spearman except for men (Pearson)

RIGHT

All correlations are Spearman except for men (Pearson)

Path Efficiency

All correlations are Spearman except for men (Pearson)

LEFT

All correlations are Spearman except for men (Pearson)

RIGHT

All correlations are Spearman except for men (Pearson)

DG

Behavioral Correlations

MAZE

Accuracy

All correlations were Spearman

LEFT

All correlations were Spearman

RIGHT

All correlations were Spearman

Moves

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

Path Efficiency

All correlations are Spearman except for men

LEFT

All correlations are Spearman except for men

RIGHT

All correlations are Spearman except for men

ERC

Behavioral Correlations

MAZE

Accuracy

All correlations were Spearman

LEFT

All correlations were Spearman

RIGHT

All correlations were Spearman

Moves

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

Path Efficiency

All correlations are Spearman except for men

LEFT

All correlations are Spearman except for men

RIGHT

All correlations are Spearman except for men

PHC

Behavioral Correlations

MAZE

Accuracy

All correlations were Spearman

LEFT

All correlations were Spearman

RIGHT

All correlations were Spearman

Moves

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

Path Efficiency

All correlations are Spearman except for men

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

PRC

Behavioral Correlations

MAZE

Accuracy

All correlations were Spearman

LEFT

All correlations were Spearman

RIGHT

All correlations were Spearman

Moves

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

Path Efficiency

Alll correlations were Spearman except for men

LEFT

All correlations were Spearman except for men

RIGHT

All correlations were Spearman except for men

SUB

Behavioral Correlations

MAZE

Accuracy

All correlations were Spearman

LEFT

All correlations were Spearman

RIGHT

All correlations were Spearman

Moves

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

Path Efficiency

Alll correlations were Spearman except for men

LEFT

All correlations were Spearman except for men

RIGHT

All correlations were Spearman except for men

Summary

Sample included HAS participants who had a T2 hipp scan and completed spatial navigation behavior for MAZE.

Total hipp Volume and MTL

  • Total hipp volume was negatively correlated with path efficiency for men.

  • There were no significant or marginal correlations observed for MTL and MAZE behaviors.

Subfields

  • There were no significant or marginal correlations observed for MAZE accuracy.

  • MAZE higher moves made was significantly negatively associated with higher right PHC volume in overall (p < 0.05, Spearman).

  • MAZE path efficiency was significantly positively associated with higher left DG in men. Path efficiency was negatively associated with total left hipp volume and right PHC volume in men. Negative correlations are also observed with averaged PRC volume for overall, and left PRC volumes for overall and for men.